Statistics show that 90% of patients with gout, the increase in uric acid is due to inability to produce sufficient amounts of uric acid through the kidneys (lack of output). The remainder is either due to large intake of purine through food (high-purine foods such as grilled chicken and sardines) or due to the production of a large amount of uric acid internally.
Renal tubules, lead poisoning, frequent drinking of alcohol, long-term use of drugs including diuretics and thiazide diuretics, aspirin, cyclosporine and pyrexamide .
As for cases where there is an increase in manufacturing, these cases are genetic diseases and result from the lack of enzymes used in the process of metabolism of purine. It is also worth noting that the increase of the uric acid industry is also produced in cases where high cell turnover, which leads to the secretion of purine (located in high concentrations in the nucleus of the cell and these cases of psoriasis and hemolytic anemia and pernicious anemia) (Myeloproliferative disorder) and lymphoproliferative disorder. Chemotherapy used in the treatment of cancer (malignant tumors), especially those associated with blood or the lymphatic system, can lead to an increase in uric acid.
The incidence of the disease also depends on the food consumed by people. The reason for the increase in uric acid may be the consumption of foods rich in borin, such as grilled chicken, sardines, fish, liver, kidneys and meat. This disease is called “disease of kings.” Fructose increases the risk of gout.
Diseases such as high blood pressure, diabetes, kidney deterioration, obesity, increased fat intake and early menopause all increase the chance of gout.
Inflammation or irritation in patients with gout occurs as a result of consuming a large amount of alcohol, eating foods high in boron in one meal, rapid increase in weight, famine (hunger), trauma, emotional stress and bleeding. It also occurs through a change in dosage of drugs that reduce or increase uric acid in the blood, including diuretics, aspirin (increased acid), alopurinol and colchicine (reduce acid).