Creatinine (creatinine) is a substance produced from creatine phosphate, a substance found in muscles. This material is produced from the body and specifically the muscles depending on the muscle mass of the body but it is a fixed rate. When the creatinine is produced, it is excreted into the blood and then taken by the kidneys to be filtered. If there is a defect in a kidney function that may affect glomerular filtration rate or GFR, the amount of creatinine that is filtered by the blood will be reduced and therefore its percentage in the blood is high. This amount in the blood of creatinine is used to determine the purity of creatinine (Clearin Clearance) or (CrCl), which in turn may help us to know (GFR).
Thus, screening the level of creatinine in the blood helps us to know the ability of the kidney to perform its functions, and also helps us to know the amount of muscle mass. As mentioned above, creatine is present in the muscles and tissues. When substances are exchanged between the muscles and blood, the creatine is converted to creatinine and then transmitted through the blood to the kidneys and filtered through it. Therefore, the greater the mass of muscles, the greater the amount of creatinine in the blood and when the mass is small, the amount of blood in the blood is low. Thus, the level of creatinine in the blood for men is higher than that in women as the muscle mass of men is greater than that of women.
As mentioned above, the high level of creatinine in the blood means that there is a defect in the kidney, including that the kidney may have been infected with bacterial infection, as well as it may mean that there is a defect in the blood vessels in the kidney, that they have been damaged or swelling as a result Infection or some autoimmune diseases. Drugs and other toxins, such as alcohol, cause the death of cells that make up small kidney tubes. The incidence of urinary tract obstruction as a result of kidney stones or as a result of prostate disease causes high levels of creatinine in the blood, and may also increase in the case of muscle injury and as a result of complications of diabetes and low blood circulation to the kidneys as a result of shock and atherosclerosis Congestive heart failure and other causes. The proportion of creatinine in the blood in the case of pregnancy, but a small percentage.