The two important organs involved in tertiary syphilis are the circulatory system and the nervous system. In the circulatory system, the disease affects the blood vessels, especially the aorta. Aorta, where the invasion of bacteria to the wall of blood vessels cirrhosis in the middle layer of the wall (tunica media), where over the years this inflammatory fibrosis leads to weakness in the wall of the aorta, resulting in aortic aneurysm aneurism, leading to the aortic incompetence of the aortic valve, so when the patient is examined by the medical device, the doctor hears a diastolic murmur.
As a result of the heart, the heart grows significantly, leading to heart enlargement and called the heart of the cow (cor bovinum). This is the heart failure is the main cause of death, and the cause of death may also be the rupture of aortic aneurysm and resulting bleeding inside the chest.