As for the location of the ulcer, it is in the genitourinary system. In males, the syphilis ulcer appears on the penis especially on the front (penis glans) or inside the urethra, followed by a viscous secretion of the duct, either in the female, the ulcer appears on the vulva, The urethra and the cervix. In females, the first stage does not sometimes appear and the disease is diagnosed in the second stage. Syphilis was found on the lips, anus, fingers, pharynx, tongue, and nipples in 10 percent of the infected.
After about a week of ulcers, the lymph nodes swell, and because the reproductive system is the infected, the lymph glands that swell are the groin lymph nodes to the upper pubic area on the sides and upper thighs, and usually heal the ulcers within 4-8 weeks automatically or with the cure .