Weak ovulation
Low ovulation or early ovarian failure, or primary ovarian insufficiency, is a failure of the ovary to perform normal functions before the age of forty. Estrogen production is lower than normal and eggs are not produced regularly. To infertility.
In the case of early ovarian failure, irregular intermittent menstrual cycles may occur for years, during which spontaneous pregnancy can occur. In the case of early menopause, the menstrual period is completely stopped and pregnancy can not occur. .
Causes of early ovarian failure
In most cases the cause of this condition is unknown, but research links them to the vesicles; the small bags that grow eggs inside and out of them at the time of ovulation. The normal number of vesicles is 2 million vesicles, which is enough to produce a woman one egg per month until reaching normal menopause, almost at the age of fifty. Women with early ovulation failure may not have enough vesicles, or the number of vesicles is enough, but they do not work properly. Possible causes of early ovulation weakness include:
- Genetic and chromosomal diseases : Such as Turner syndrome, X syndrome and fragile X chromosome.
- Low number of vesicles : Some women are born with a low stock of primary vesicles, so the number of vesicles they produce is less than expected. Although one follicle matures and produces an egg every month, it is observed that immature vesicles develop alongside the mature follicle. In the absence of these vesicles In support, ovulation is not done properly.
- Autoimmune diseases : The immune system attacks the vesicles inside the ovary, and may attack the glands that secrete the hormones necessary for the work of the ovaries and vesicles.
- Chemotherapy or radiotherapy Cancer treatment may damage the genetic material in cells, including follicular cells.
- Disorders of metabolism : These disorders affect the ability of the body to produce, store and use the energy it needs, as in the case of galactosemia, a disorder that affects the body’s ability to digest galactose.
- Toxins : Such as cigarette smoke, chemicals, pesticides, and some viruses may affect the functions of the vesicles.
- Hysterectomy Or any surgery in the pelvis.
Symptoms of early ovulation weakness
Symptoms of weak ovulation are almost similar to early menopause symptoms including:
Diagnosis of early ovulation weakness
To diagnose the disease of weak ovulation, the doctor may resort to the following tests:
- pregnancy test.
- Measuring the level of the follicle stimulating hormone.
- Measure the level of the lutein hormone.
- Measure the level of estradiol; a type of estrogen in the serum.
- DNA analysis, a test that examines chromosomes to determine if there is an abnormality. Some women with early ovarian failure may have a chromosome (x) instead of two, or defects in other chromosomes.
- Test the FMR1 genes to detect the presence of fragile x chromosome syndrome or mental retardation.
- Check antibodies in the body that may affect the ovary or adrenal gland.
- Studying the history of the family.
- Enzyme peroxidase against thyroid.
- Ultrasound imaging.
- Check the level of antacids.
- Clinical examination of the patient.
Complications of weak ovulation disease
Women with ovulatory weakness may suffer from one or more of the following complications:
Methods of treatment of ovulation weakness
There is currently no treatment for early ovulation failure, but the associated symptoms can be treated and the risks associated with it reduced, and some cases where the ovaries have recovered their ability to function automatically without medical intervention have been recorded after diagnosis of early failure. The treatment is as follows:
- Hormone Replacement Therapy :
- Estrogen: Estrogen supply of the body improves sexual health, reduces the risk of cardiovascular disease (including heart attacks, stroke, high blood pressure).
- The patient can be given a mixture of estrogen, progestin, and sometimes testosterone.
- A mixture of estradiol (the natural form of estrogen), and progestin.
- Hormone hydroxyprogesterone acetate.
- Hormone replacement therapy may be in several forms, such as oral contraceptives, gelatinous creams, skin patches, intrauterine devices, or vaginal rings. It is worth mentioning that giving long-term alternative hormones increases the risk of heart disease, blood vessels, and breast cancer.
- Calcium and Vitamin D : Women with early ovulation failure are more likely to develop osteoporosis, so it is important to provide them with calcium, and vitamin D, which helps absorb calcium, the doctor may suggest a bone density test.
- Exercise : Physical activity, such as walking, jogging, climbing stairs, carrying weights helps build bone strength, prevents brittleness, maintains a healthy weight of the body, reduces the risk of heart disease, and reduces the level of cholesterol.
- Treatment of health disorders causing ovulation failure, such as thyroid disorders, Addison’s disease, X chromosome syndrome fragile, depression, anxiety, metabolic and genetic disorders.
- Emotional support : Suffering from emotional disorders and anxiety.
- A study on the possibility of producing mature eggs using stem cells , Where it has been discovered that the ovulation of female newborns and adults may contain a small number of stem cells that can reproduce and produce eggs if injected injecting animal lab experiments, and if applied this method, which needs more tests and clinical tests, For women with ovarian weakness who want to have children.
Coexistence with early ovulation weakness disease
The patient can live with this disease and enjoy life if she complies with the following instructions: