The causes of Edison’s disease are numerous, but the main cause of Edison’s disease is autoimmune immunity, which occurs in the form of atrophy, fibrosis, lymphocytic infiltration and infiltration of the lymphatic glands. These changes are absent in the pulp layer, The disease may be a part of the polyglandular autoimmune disease. It is a disease that is considered to be present in the patient’s examination of pernicious anemia and a deficiency in the thyroid gland. And hypothyroidism due to inflammation himoto thyroiditis), insulin-dependent diabetes, vitiligo and premature premature ovulation of women or testicles in men, pituitary insufficiency and underlying disease
(celiac disease).
Other causes of Edison’s disease are tuberculosis, leprosy, sarcoidosis, amyloidosis,
(hemochromatosis), as well as tumors that can attack the gland and are damaged, especially tumors of the lymph nodes (Hodgkin and non-hodgkin lymphoma) and leukemia (leukemia).
In rare cases, the disease causes AIDS. It is worth mentioning that infarction due to thrombosis in both of the two cities, especially in patients with sickle cell anemia, leads to the disease of Edison and on the other hand, bleeding also causes it.